I learned to fly at a grass field (Oxford, PA, now closed) that was steeply sloped down to the south with several humps along the way. When the wind was not strongly favoring the north runway or the south runway, we took off downhill and landed uphill. It was an interesting experience to have to check the end of downwind, around the bass leg and final for traffic landing opposite to your pending departure. This was routine, so local pilots knew the drill. By the way, we said "...departing to the north" or "departing to the south", not "36" or "18".
The crossing runway along the top of the hill was 2000' with powerlines at the east end and trees at the west end. So needless to say, we used that ONLY when there was a significant east or west wind, otherwise, the C-150 trainer might not clear the obstacles......and I came close more than once. It teaches you something.