Do you remember Flight 522 operated by HELIOS AIRWAYS when both pilots became unconscious because faulty presurisation systems ... not a chance of happening something similar...?

Is there a chance? Yes. Is it likely / probable? No! Since the flight deck shares the same presurization / air supply as the cabin (Unless they where on Supplemantal 02), there would have been somebody else (Cabin crew) that would have lost conscioness too, and would have said something.
I am not sure about Airbus (If someone knows, please chime in). but at least on the Boeing 768/744. Once you get within about 20KM of your T/D (Top of decent.) if you have not already done so, you will get a chime, and an EICAS message, and Amber Master Caution to RESET MCP ALT. (Which is an indication for the flight crew to enter their next lowest hard altitude in the Altitude selector on the Mode Control Panel.
How did they also miss the SELCAL chime when their company called. The 744 also has a company option that if no buttons or radio trasmissions are made within a certain time, a warning alarm sounds, and you get a "NO CREW SLEEPING" message on the EICAS...